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Target
Serine/threonine-protein kinase pim-1
Ligand
BDBM227249
Substrate
n/a
Meas. Tech.
PIM Kinase Binding Assay
pH
7.2±n/a
Temperature
298.15±n/a K
Ki
0.011±n/a nM
Comments
extracted
Citation
 Burch, J; Sun, M; Wang, X; Blackaby, W; Hodges, AJ; Sharpe, A Cyclic ether pyrazol-4-yl-heterocyclyl-carboxamide compounds and methods of use US Patent  US9328106 Publication Date 5/3/2016 
Target
Name:
Serine/threonine-protein kinase pim-1
Synonyms:
PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:
Protein
Mol. Mass.:
35681.82
Organism:
Homo sapiens (Human)
Description:
P11309
Residue:
313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
  
Inhibitor
Name:
BDBM227249
Synonyms:
US9328106, 200
Type:
Small organic molecule
Emp. Form.:
C25H27F4N5O3
Mol. Mass.:
521.5072
SMILES:
Cn1ncc(NC(=O)c2ccc(F)c(n2)-c2c(F)cc(cc2F)C(C)(C)O)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 |r,wU:31.34,wD:28.30,33.36,(-5.48,4.02,;-5.48,2.48,;-6.73,1.58,;-6.25,.11,;-4.71,.11,;-3.94,-1.22,;-3.94,-2.76,;-5.28,-3.53,;-2.61,-3.53,;-2.61,-5.07,;-1.27,-5.84,;.06,-5.07,;1.39,-5.84,;.06,-3.53,;-1.27,-2.76,;1.39,-2.76,;1.39,-1.22,;.06,-.45,;2.73,-.45,;4.06,-1.22,;4.06,-2.76,;2.73,-3.53,;2.73,-5.07,;5.39,-.45,;5.39,1.09,;6.73,-1.22,;6.73,.32,;-4.24,1.58,;-2.9,2.35,;-2.9,3.89,;-1.7,4.85,;-.2,4.51,;.57,5.84,;.47,3.12,;1.96,2.72,;-.2,1.73,;-1.7,1.39,)|
Structure:
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