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Target
Serine/threonine-protein kinase pim-1
Ligand
BDBM227257
Substrate
n/a
Meas. Tech.
PIM Kinase Binding Assay
pH
7.2±n/a
Temperature
298.15±n/a K
Ki
0.012±n/a nM
Comments
extracted
Citation
 Burch, J; Sun, M; Wang, X; Blackaby, W; Hodges, AJ; Sharpe, A Cyclic ether pyrazol-4-yl-heterocyclyl-carboxamide compounds and methods of use US Patent  US9328106 Publication Date 5/3/2016 
Target
Name:
Serine/threonine-protein kinase pim-1
Synonyms:
PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:
Protein
Mol. Mass.:
35681.82
Organism:
Homo sapiens (Human)
Description:
P11309
Residue:
313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
  
Inhibitor
Name:
BDBM227257
Synonyms:
US9328106, 208
Type:
Small organic molecule
Emp. Form.:
C22H21F4N5O3
Mol. Mass.:
479.4275
SMILES:
Cn1ncc(NC(=O)c2ccc(F)c(n2)-c2c(F)cc(O)cc2F)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 |r,wU:28.31,wD:25.27,30.33,(-4.81,4.02,;-4.81,2.48,;-6.06,1.58,;-5.58,.11,;-4.04,.11,;-3.27,-1.22,;-3.27,-2.76,;-4.61,-3.53,;-1.94,-3.53,;-1.94,-5.07,;-.61,-5.84,;.73,-5.07,;2.06,-5.84,;.73,-3.53,;-.61,-2.76,;2.06,-2.76,;2.06,-1.22,;.73,-.45,;3.39,-.45,;4.73,-1.22,;6.06,-.45,;4.73,-2.76,;3.39,-3.53,;3.39,-5.07,;-3.57,1.58,;-2.24,2.35,;-2.24,3.89,;-1.03,4.85,;.47,4.51,;1.24,5.84,;1.14,3.12,;2.63,2.72,;.47,1.73,;-1.03,1.39,)|
Structure:
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