Reaction Details Report a problem with these data
Target
Histamine H4 receptor
Ligand
BDBM181150
Substrate
n/a
Meas. Tech.
Binding Assay
Ki
2000±n/a nM
Citation
 Aberg, AK; Ciofalo, VB Methods of treatment of histamine H-4 receptor-related pruritus associated with nerve disorders US Patent  US9333199 Publication Date 5/10/2016 
Target
Name:
Histamine H4 receptor
Synonyms:
AXOR35 | G-protein coupled receptor 105 | GPCR105 | GPRv53 | HH4R | HISTAMINE H4 | HRH4 | HRH4_HUMAN | Histamine H4 receptor | Histamine H4 receptor (H4R) | Histamine receptor (H3 and H4) | Pfi-013 | SP9144
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44517.02
Organism:
Homo sapiens (Human)
Description:
Binding assays were using CHO cells stably expressing hH4R receptors.
Residue:
390
Sequence:
MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDFFVGVISIPLYIPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAVSYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWKDEGSECEPGFFSEWYILAITSFLEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSASTEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPLCHKRFQKAFLKIFCIKKQPLPSQHSRSVSS
  
Inhibitor
Name:
BDBM181150
Synonyms:
US9138431, R-NORKETOTIFEN (RNORK) | US9138431, RS-NORKETOTIFEN (NORK) | US9138431, RS-NORKETOTIFEN (RSNORK) | US9138431, S-NORKETOTIFEN (SNORK) | US9333199, RS-NORKETOTIFEN (NORK)
Type:
Small organic molecule
Emp. Form.:
C18H17NOS
Mol. Mass.:
295.399
SMILES:
O=[#6]-1-[#6]-c2ccccc2\[#6](-c2ccsc-12)=[#6]-1/[#6]-[#6]-[#7]-[#6]-[#6]-1
Structure:
Search PDB for entries with ligand similarity: