Reaction Details Report a problem with these data
Target
Hexokinase-4
Ligand
BDBM229604
Substrate
n/a
Meas. Tech.
Coupled Enzymatic Assay
pH
7.2±n/a
EC50
660±n/a nM
Comments
extracted
Citation
 Bhuniya, D; Deshpande, A; Kandalkar, S; Kobal, B; Kurhade, S; Vyavahare, V; Kaduskar, R Acetamide derivatives as glucokinase activators, their process and medicinal applications US Patent  US9340506 Publication Date 5/17/2016 
Target
Name:
Hexokinase-4
Synonyms:
GCK | Glucokinase (GCK) | Glucokinase (GK) | Glucokinase/Glucokinase regulatory protein | HK IV | HK4 | HXK4_HUMAN | Hexokinase-4 | Hexokinase-D
Type:
Enzyme
Mol. Mass.:
52175.81
Organism:
Homo sapiens (Human)
Description:
P35557
Residue:
465
Sequence:
MLDDRARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ
  
Inhibitor
Name:
BDBM229604
Synonyms:
US9340506, A-12
Type:
Small Organic Molecule
Emp. Form.:
C24H28N4O7S2
Mol. Mass.:
548.632
SMILES:
COc1ccc2nc(NC(=O)C(OC3CCOCC3)c3ccc(cc3)S(=O)(=O)N3CCOCC3)sc2n1
Structure:
Search PDB for entries with ligand similarity: