Reaction Details Report a problem with these data
Target
Hexokinase-4
Ligand
BDBM229619
Substrate
n/a
Meas. Tech.
Coupled Enzymatic Assay
pH
7.2±n/a
EC50
1200±0 nM
Comments
extracted
Citation
 Bhuniya, D; Deshpande, A; Kandalkar, S; Kobal, B; Kurhade, S; Vyavahare, V; Kaduskar, R Acetamide derivatives as glucokinase activators, their process and medicinal applications US Patent  US9340506 Publication Date 5/17/2016 
Target
Name:
Hexokinase-4
Synonyms:
GCK | Glucokinase (GCK) | Glucokinase (GK) | Glucokinase/Glucokinase regulatory protein | HK IV | HK4 | HXK4_HUMAN | Hexokinase-4 | Hexokinase-D
Type:
Enzyme
Mol. Mass.:
52175.81
Organism:
Homo sapiens (Human)
Description:
P35557
Residue:
465
Sequence:
MLDDRARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ
  
Inhibitor
Name:
BDBM229619
Synonyms:
US9340506, E3
Type:
Small Organic Molecule
Emp. Form.:
C22H20F2N2O6S2
Mol. Mass.:
510.531
SMILES:
OCC(O)c1cnc(NC(=O)C(Oc2ccc(F)cc2F)c2ccc(cc2)S(=O)(=O)C2CC2)s1
Structure:
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