Reaction Details Report a problem with these data
Target
Hexokinase-4
Ligand
BDBM228464
Substrate
n/a
Meas. Tech.
Coupled Enzymatic Assay
pH
7.2±n/a
EC50
260±0 nM
Comments
extracted
Citation
 Bhuniya, D; Deshpande, A; Kandalkar, S; Kobal, B; Kurhade, S; Vyavahare, V; Kaduskar, R Acetamide derivatives as glucokinase activators, their process and medicinal applications US Patent  US9340506 Publication Date 5/17/2016 
Target
Name:
Hexokinase-4
Synonyms:
GCK | Glucokinase (GCK) | Glucokinase (GK) | Glucokinase/Glucokinase regulatory protein | HK IV | HK4 | HXK4_HUMAN | Hexokinase-4 | Hexokinase-D
Type:
Enzyme
Mol. Mass.:
52175.81
Organism:
Homo sapiens (Human)
Description:
P35557
Residue:
465
Sequence:
MLDDRARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ
  
Inhibitor
Name:
BDBM228464
Synonyms:
BDBM229621 | US9340506, G4B
Type:
Small organic molecule
Emp. Form.:
C23H18F2N4O4S2
Mol. Mass.:
516.54
SMILES:
Fc1ccc(OC(C(=O)Nc2ncc(s2)-n2cccn2)c2ccc(cc2)S(=O)(=O)C2CC2)c(F)c1
Structure:
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