Reaction Details Report a problem with these data
Target
E3 ubiquitin-protein ligase XIAP [241-356]
Ligand
BDBM228592
Substrate
n/a
Meas. Tech.
TR-FRET Assay
pH
7.5±n/a
Temperature
310.15±n/a K
IC50
>54.8±n/a nM
Comments
extracted
Citation
 Hogg, JH; Lou, Y Azaindolines US Patent  US9340573 Publication Date 5/17/2016 
Target
Name:
E3 ubiquitin-protein ligase XIAP [241-356]
Synonyms:
API3 | BIRC4 | Baculoviral IAP repeat (BIR) domains BIR3 | IAP3 | XIAP | XIAP_HUMAN
Type:
Protein
Mol. Mass.:
14528.99
Organism:
Artificial Sequence
Description:
6x Histidine-tagged BIR3 domain (241-356 aa of XIAP)
Residue:
125
Sequence:
MRHHHHHHRSDAVSSDRNFPNSTNLPRNPSMADYEARIFTEGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTT
  
Inhibitor
Name:
BDBM228592
Synonyms:
US9340573, 3
Type:
Small organic molecule
Emp. Form.:
C19H30N6O3
Mol. Mass.:
390.4799
SMILES:
CN[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N1[C@H](CNC(=O)NC)Cc2cccnc12
Structure:
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