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Target
Tyrosine-protein kinase JAK2 [808-1132]
Ligand
BDBM228708
Substrate
n/a
Meas. Tech.
Enzymatic Assay
Temperature
298.15±n/a K
IC50
0.55±0.55 nM
Comments
extracted
Citation
 Su, W; Deng, W; Li, J; Ji, J Pyrrolopyrimidine compounds and uses thereof US Patent  US9346810 Publication Date 5/24/2016 
Target
Name:
Tyrosine-protein kinase JAK2 [808-1132]
Synonyms:
JAK2 | JAK2_HUMAN | Janus kinase 2 (JAK2) | Tyrosine-protein kinase JAK2 | Tyrosine-protein kinase JAK2 (808-1132)
Type:
n/a
Mol. Mass.:
37984.02
Organism:
Homo sapiens (Human)
Description:
808-1132 aa of O60674
Residue:
325
Sequence:
LFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG
  
Inhibitor
Name:
BDBM228708
Synonyms:
US10369153, Compound 259 | US9346810, 259
Type:
Small Organic Molecule
Emp. Form.:
C21H27N7O3S
Mol. Mass.:
457.549
SMILES:
CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccc(cn1)S(=O)(=O)NC1CCOCC1
Structure:
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