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Target
Mitogen-activated protein kinase 1
Ligand
BDBM233429
Substrate
n/a
Meas. Tech.
Active ERK2 (aERK) Assay
IC50
31.3±n/a nM
Citation
 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Indazole derivatives useful as ERK inhibitors US Patent  US9351965 Publication Date 5/31/2016 
Target
Name:
Mitogen-activated protein kinase 1
Synonyms:
ERT1 | Erk2 | Extracellular signal-regulated kinase 2 | Extracellular signal-regulated kinase 2 (ERK2) | MAP kinase 1 | MAP kinase 2 | MAP kinase ERK2 | MAPK 1 | MAPK 2 | MK01_MOUSE | Mapk | Mapk1 | Mitogen-activated protein kinase 2 | Prkm1 | p42 | p42-MAPK
Type:
Protein
Mol. Mass.:
41278.65
Organism:
Mus musculus (Mouse)
Description:
P63085
Residue:
358
Sequence:
MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS
  
Inhibitor
Name:
BDBM233429
Synonyms:
US9351965, 140 | US9351965, 141 | US9351965, 36
Type:
Small organic molecule
Emp. Form.:
C25H24ClN5O2
Mol. Mass.:
461.943
SMILES:
Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NN1CCCC(C1)Oc1ccccc1Cl
Structure:
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