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Target
UDP-glucuronosyltransferase 1-6
Ligand
BDBM234401
Substrate
1-Naphthol
Meas. Tech.
UDP-glucuronosyltransferase Activity Assay
IC50
>3.00e+5±n/a nM
Citation
 Liu, Y; She, M; Wu, Z; Dai, R The inhibition study of human UDP-glucuronosyltransferases with cytochrome P450 selective substrates and inhibitors. J Enzyme Inhib Med Chem 26:386-93 (2011) [PubMed]  Article 
Target
Name:
UDP-glucuronosyltransferase 1-6
Synonyms:
GNT1 | Phenol-metabolizing UDP-glucuronosyltransferase | UD16_HUMAN | UDP-glucuronosyltransferase 1-6 | UDP-glucuronosyltransferase 1-F | UDP-glucuronosyltransferase 1A6 | UDPGT 1-6 | UGT-1F | UGT1 | UGT1*6 | UGT1-06 | UGT1.6 | UGT1A6 | UGT1F | Uridine-5'-diphosphoglucuronosyltransferase 1A6
Type:
Enzyme
Mol. Mass.:
60765.14
Organism:
Homo sapiens (Human)
Description:
P19224
Residue:
532
Sequence:
MACLLRSFQRISAGVFFLALWGMVVGDKLLVVPQDGSHWLSMKDIVEVLSDRGHEIVVVVPEVNLLLKESKYYTRKIYPVPYDQEELKNRYQSFGNNHFAERSFLTAPQTEYRNNMIVIGLYFINCQSLLQDRDTLNFFKESKFDALFTDPALPCGVILAEYLGLPSVYLFRGFPCSLEHTFSRSPDPVSYIPRCYTKFSDHMTFSQRVANFLVNLLEPYLFYCLFSKYEELASAVLKRDVDIITLYQKVSVWLLRYDFVLEYPRPVMPNMVFIGGINCKKRKDLSQEFEAYINASGEHGIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH
  
Inhibitor
Name:
BDBM234401
Synonyms:
Oleandomycin
Type:
Small organic molecule
Emp. Form.:
C35H61NO12
Mol. Mass.:
687.8583
SMILES:
CO[C@H]1C[C@H](O[C@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@@H]([C@H]3O)N(C)C)[C@@H](C)C[C@@]3(CO3)C(=O)[C@H](C)[C@@H](O)[C@@H](C)[C@@H](C)OC(=O)[C@@H]2C)O[C@@H](C)[C@@H]1O
Structure:
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Substrate
Name:
BDBM23450
Synonyms:
1-Naphthalenol | 1-Naphthol | CHEMBL122617 | Naphth-1-ol, 9 | alpha-naphthol | naphthalen-1-ol
Type:
Small organic molecule
Emp. Form.:
C10H8O
Mol. Mass.:
144.1699
SMILES:
Oc1cccc2ccccc12
Structure:
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