Reaction Details Report a problem with these data
Target
Isoform PDE4B2 of cAMP-specific 3',5'-cyclic phosphodiesterase 4B (PDE4B2)
Ligand
BDBM135814
Substrate
n/a
Meas. Tech.
TR-FRET-Based Assay
Temperature
303.15±n/a K
IC50
12400±n/a nM
Comments
extracted
Citation
 Mjalli, AM; Gaddam, B; Polisetti, DR; Kostura, MJ; Guzel, M Tricyclic compounds as modulators of TNF-alpha synthesis and as PDE4 inhibitors US Patent  US9393245 Publication Date 7/19/2016 
Target
Name:
Isoform PDE4B2 of cAMP-specific 3',5'-cyclic phosphodiesterase 4B (PDE4B2)
Synonyms:
DPDE4 | PDE4B | PDE4B2 | PDE4B_HUMAN | cAMP-specific 3',5'-cyclic phosphodiesterase 4B (PDE4B2) | phosphodiesterase 4B2
Type:
Enzyme
Mol. Mass.:
64320.36
Organism:
Homo sapiens (Human)
Description:
Q07343-2
Residue:
564
Sequence:
MKEHGGTFSSTGISGGSGDSAMDSLQPLQPNYMPVCLFAEESYQKLAMETLEELDWCLDQLETIQTYRSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKKKQQLMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSPSPPLDEQNRDCQGLMEKFQFELTLDEEDSEGPEKEGEGHSYFSSTKTLCVIDPENRDSLGETDIDIATEDKSPVDT
  
Inhibitor
Name:
BDBM135814
Synonyms:
US10085990, Example 33 | US10568888, Example 33 | US8853226, 33 | US9393245, 33 | US9833457, 33
Type:
Small organic molecule
Emp. Form.:
C21H25N3O2
Mol. Mass.:
351.4421
SMILES:
CCn1c(=O)n(C2CCCC2)c2c3cccc(C(C)C)c3ncc2c1=O
Structure:
Search PDB for entries with ligand similarity: