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Target
Lysosomal Pro-X carboxypeptidase
Ligand
BDBM235958
Substrate
n/a
Meas. Tech.
Enzyme Activity Assay
pH
5.5±n/a
IC50
1.28±n/a nM
Comments
extracted
Citation
 Hale, JJ; Jiang, J; Shen, D; Shi, Z; Shu, M; Wu, Z; Yang, C Prolylcarboxypeptidase inhibitors US Patent  US9365539 Publication Date 6/14/2016 
Target
Name:
Lysosomal Pro-X carboxypeptidase
Synonyms:
Angiotensinase C | Lysosomal carboxypeptidase C | PCP | PCP_HUMAN | PRCP | Proline carboxypeptidase | Prolylcarboxypeptidase | Prolylcarboxypeptidase (PRCP)
Type:
Enzyme
Mol. Mass.:
55805.19
Organism:
Homo sapiens (Human)
Description:
P42785
Residue:
496
Sequence:
MGRRALLLLLLSFLAPWATIALRPALRALGSLHLPTNPTSLPAVAKNYSVLYFQQKVDHFGFNTVKTFNQRYLVADKYWKKNGGSILFYTGNEGDIIWFCNNTGFMWDVAEELKAMLVFAEHRYYGESLPFGDNSFKDSRHLNFLTSEQALADFAELIKHLKRTIPGAENQPVIAIGGSYGGMLAAWFRMKYPHMVVGALAASAPIWQFEDLVPCGVFMKIVTTDFRKSGPHCSESIHRSWDAINRLSNTGSGLQWLTGALHLCSPLTSQDIQHLKDWISETWVNLAMVDYPYASNFLQPLPAWPIKVVCQYLKNPNVSDSLLLQNIFQALNVYYNYSGQVKCLNISETATSSLGTLGWSYQACTEVVMPFCTNGVDDMFEPHSWNLKELSDDCFQQWGVRPRPSWITTMYGGKNISSHTNIVFSNGELDPWSGGGVTKDITDTLVAVTISEGAHHLDLRTKNALDPMSVLLARSLEVRHMKNWIRDFYDSAGKQH
  
Inhibitor
Name:
BDBM235958
Synonyms:
US9365539, 68
Type:
Small organic molecule
Emp. Form.:
C27H23F4N5O
Mol. Mass.:
509.498
SMILES:
Fc1ccc(cc1)-c1cc(C2CCN(CC2)C(=O)Cc2ccccc2C(F)(F)F)n(n1)-c1ncccn1
Structure:
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