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Target
Gag-Pol polyprotein [489-587,Q496K]
Ligand
BDBM293267
Substrate
n/a
Meas. Tech.
Inhibition of HIV Replication
pH
7.55±n/a
EC50
550±n/a nM
Comments
extracted
Citation
 Kadow, JF; Naidu, BN; Tu, Y Pyridin-3-yl acetic acid derivatives as inhibitors of human immunodeficiency virus replication US Patent  US10106504 Publication Date 10/23/2018 
Target
Name:
Gag-Pol polyprotein [489-587,Q496K]
Synonyms:
HIV-1 Protease Chain A | HIV-1 Protease NL4-3 | POL_HV1N5 | gag-pol
Type:
Enzyme Subunit
Mol. Mass.:
10823.26
Organism:
Human immunodeficiency virus type 1
Description:
P12497[489-587,Q496K]
Residue:
99
Sequence:
PQITLWKRPLVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYDQILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
  
Inhibitor
Name:
BDBM293267
Synonyms:
US10106504, Example 4
Type:
Small organic molecule
Emp. Form.:
C41H43NO7
Mol. Mass.:
661.7826
SMILES:
COc1ccc(COc2ccc(cc2)-c2c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c2-c2ccc(OCc3ccc(OC)cc3)cc2)cc1 |r|
Structure:
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