Reaction Details Report a problem with these data
Target
Cholinesterase
Ligand
BDBM293401
Substrate
n/a
Meas. Tech.
Measurement of IC50 of Eckol Derivatives Against Acetylcholinesterase and Butyrylcholinesterase
pH
7.4±n/a
Temperature
298.15±n/a K
IC50
1400±n/a nM
Comments
extracted
Citation
 Shin, H; Hwang, H; Park, KY; Kim, SH; Lee, H Eckol derivatives, methods of synthesis and uses thereof US Patent  US10106521 Publication Date 10/23/2018 
Target
Name:
Cholinesterase
Synonyms:
Acylcholine acylhydrolase | BCHE | Butyrylcholine esterase (BChE) | Butyrylcholinesterase (BChE) | Butyrylcholinesterase (BuChE) | CHE1 | CHLE_HUMAN | Choline esterase II | Cholinesterases | Cholinesterases; ACHE & BCHE | Pseudocholinesterase
Type:
Homotetramer
Mol. Mass.:
68422.27
Organism:
Homo sapiens (Human)
Description:
P06276
Residue:
602
Sequence:
MHSKVTIICIRFLFWFLLLCMLIGKSHTEDDIIIATKNGKVRGMNLTVFGGTVTAFLGIPYAQPPLGRLRFKKPQSLTKWSDIWNATKYANSCCQNIDQSFPGFHGSEMWNPNTDLSEDCLYLNVWIPAPKPKNATVLIWIYGGGFQTGTSSLHVYDGKFLARVERVIVVSMNYRVGALGFLALPGNPEAPGNMGLFDQQLALQWVQKNIAAFGGNPKSVTLFGESAGAASVSLHLLSPGSHSLFTRAILQSGSFNAPWAVTSLYEARNRTLNLAKLTGCSRENETEIIKCLRNKDPQEILLNEAFVVPYGTPLSVNFGPTVDGDFLTDMPDILLELGQFKKTQILVGVNKDEGTAFLVYGAPGFSKDNNSIITRKEFQEGLKIFFPGVSEFGKESILFHYTDWVDDQRPENYREALGDVVGDYNFICPALEFTKKFSEWGNNAFFYYFEHRSSKLPWPEWMGVMHGYEIEFVFGLPLERRDNYTKAEEILSRSIVKRWANFAKYGNPNETQNNSTSWPVFKSTEQKYLTLNTESTRIMTKLRAQQCRFWTSFFPKVLEMTGNIDEAEWEWKAGFHRWNNYMMDWKNQFNDYTSKKESCVGL
  
Inhibitor
Name:
BDBM293401
Synonyms:
US10106521, Compound 9''-O-Methyl Dieckol
Type:
Small organic molecule
Emp. Form.:
C37H24O18
Mol. Mass.:
756.5757
SMILES:
COc1cc(Oc2c(O)cc(Oc3c(O)cc(O)c4Oc5cc(O)cc(O)c5Oc34)cc2O)cc2Oc3c(O)cc(O)c(Oc4cc(O)cc(O)c4)c3Oc12
Structure:
Search PDB for entries with ligand similarity: