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Target
Acetylcholinesterase
Ligand
BDBM50276756
Substrate
n/a
Meas. Tech.
Measurement of IC50 of Eckol Derivatives Against Acetylcholinesterase and Butyrylcholinesterase
pH
7.4±n/a
Temperature
298.15±n/a K
IC50
94100±n/a nM
Comments
extracted
Citation
 Shin, H; Hwang, H; Park, KY; Kim, SH; Lee, H Eckol derivatives, methods of synthesis and uses thereof US Patent  US10106521 Publication Date 10/23/2018 
Target
Name:
Acetylcholinesterase
Synonyms:
ACES_HUMAN | ACHE | Acetylcholinesterase (AChE) | Acetylcholinesterase (human AChE)
Type:
Enzyme
Mol. Mass.:
67792.70
Organism:
Homo sapiens (Human)
Description:
P22303
Residue:
614
Sequence:
MRPPQCLLHTPSLASPLLLLLLWLLGGGVGAEGREDAELLVTVRGGRLRGIRLKTPGGPVSAFLGIPFAEPPMGPRRFLPPEPKQPWSGVVDATTFQSVCYQYVDTLYPGFEGTEMWNPNRELSEDCLYLNVWTPYPRPTSPTPVLVWIYGGGFYSGASSLDVYDGRFLVQAERTVLVSMNYRVGAFGFLALPGSREAPGNVGLLDQRLALQWVQENVAAFGGDPTSVTLFGESAGAASVGMHLLSPPSRGLFHRAVLQSGAPNGPWATVGMGEARRRATQLAHLVGCPPGGTGGNDTELVACLRTRPAQVLVNHEWHVLPQESVFRFSFVPVVDGDFLSDTPEALINAGDFHGLQVLVGVVKDEGSYFLVYGAPGFSKDNESLISRAEFLAGVRVGVPQVSDLAAEAVVLHYTDWLHPEDPARLREALSDVVGDHNVVCPVAQLAGRLAAQGARVYAYVFEHRASTLSWPLWMGVPHGYEIEFIFGIPLDPSRNYTAEEKIFAQRLMRYWANFARTGDPNEPRDPKAPQWPPYTAGAQQYVSLDLRPLEVRRGLRAQACAFWNRFLPKLLSATDTLDEAERQWKAEFHRWSSYMVHWKNQFDHYSKQDRCSDL
  
Inhibitor
Name:
BDBM50276756
Synonyms:
4,9-bis(3,5-dihydroxyphenoxy)benzofuro[3,2-a]dibenzo[b,e][1,4]dioxine-1,3,6,10,12-pentaol | CHEMBL510508 | Phlorofucofuroeckol-A | US10106521, Compound Phlorofucofuroeckol A | phlorofucofuroeckol A
Type:
Small organic molecule
Emp. Form.:
C30H18O14
Mol. Mass.:
602.4555
SMILES:
Oc1cc(O)cc(Oc2c(O)cc(O)c3Oc4c(Oc23)c(O)cc2oc3c(Oc5cc(O)cc(O)c5)c(O)cc(O)c3c42)c1
Structure:
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