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Target
E3 ubiquitin-protein ligase SMURF1 [420-757]
Ligand
BDBM239100
Substrate
n/a
Meas. Tech.
Biochemical Assay
Temperature
298.15±n/a K
IC50
64±n/a nM
Comments
extracted
Citation
 Bala, KJ; Brearley, A; Dale, J; Edwards, A; Ahmed, M; Porter, D; Pulz, RA; Rooney, LA; Sandham, DA; Shaw, D; Smith, N; Taylor, JL; Taylor, RJ; Troxler, TJ; Wrigglesworth, J Carboxamide derivatives US Patent  US9403810 Publication Date 8/2/2016 
Target
Name:
E3 ubiquitin-protein ligase SMURF1 [420-757]
Synonyms:
HECT-type E3 ubiquitin transferase SMURF1 | KIAA1625 | SMUF1_HUMAN | SMURF1
Type:
Enzyme
Mol. Mass.:
39188.96
Organism:
Homo sapiens (Human)
Description:
HECTdomain amino acid 420-757
Residue:
338
Sequence:
RPKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSSINPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILENDITPVLDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKHCVADSNIVRWFWQAVETFDEERRARLLQFVTGSTRVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGFAVE
  
Inhibitor
Name:
BDBM239100
Synonyms:
US10195181, Example 2.1 | US9403810, 2.1
Type:
Small organic molecule
Emp. Form.:
C25H34N4O4
Mol. Mass.:
454.5619
SMILES:
Cc1c(noc1C1=CCC2(CCCO2)CC1)C(=O)Nc1c(C)n(C)n(C2CCCCC2)c1=O |t:7|
Structure:
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