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Target
E3 ubiquitin-protein ligase SMURF1 [420-757]
Ligand
BDBM239115
Substrate
n/a
Meas. Tech.
Biochemical Assay
Temperature
298.15±n/a K
IC50
180±n/a nM
Comments
extracted
Citation
 Bala, KJ; Brearley, A; Dale, J; Edwards, A; Ahmed, M; Porter, D; Pulz, RA; Rooney, LA; Sandham, DA; Shaw, D; Smith, N; Taylor, JL; Taylor, RJ; Troxler, TJ; Wrigglesworth, J Carboxamide derivatives US Patent  US9403810 Publication Date 8/2/2016 
Target
Name:
E3 ubiquitin-protein ligase SMURF1 [420-757]
Synonyms:
HECT-type E3 ubiquitin transferase SMURF1 | KIAA1625 | SMUF1_HUMAN | SMURF1
Type:
Enzyme
Mol. Mass.:
39188.96
Organism:
Homo sapiens (Human)
Description:
HECTdomain amino acid 420-757
Residue:
338
Sequence:
RPKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSSINPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILENDITPVLDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKHCVADSNIVRWFWQAVETFDEERRARLLQFVTGSTRVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGFAVE
  
Inhibitor
Name:
BDBM239115
Synonyms:
US10195181, Example 20 | US9403810, 20
Type:
Small organic molecule
Emp. Form.:
C23H34N4O5
Mol. Mass.:
446.5399
SMILES:
C[C@@H]1OC(C)(C)CO[C@H]1c1onc(C(=O)Nc2c(C)n(C)n(C3CCCCC3)c2=O)c1C |r|
Structure:
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