Reaction Details Report a problem with these data
Target
Rho-associated protein kinase 1 [1-535]
Ligand
BDBM50382700
Substrate
n/a
Meas. Tech.
FRET-Based Enzyme-Coupled Assay
pH
7.5±n/a
Temperature
298.15±n/a K
IC50
270000±51000 nM
Comments
extracted
Citation
 Schonbrunn, E; Li, R; Sebti, SM Inhibitors of rho associated protein kinases (ROCK) and methods of use US Patent  US9409868 Publication Date 8/9/2016 
Target
Name:
Rho-associated protein kinase 1 [1-535]
Synonyms:
ROCK1 | ROCK1_HUMAN | Rho-associated protein kinase 1 (ROCK1)
Type:
Enzyme
Mol. Mass.:
62220.48
Organism:
Homo sapiens (Human)
Description:
aa 1-535
Residue:
535
Sequence:
MSTGDSFETRFEKMDNLLRDPKSEVNSDCLLDGLDALVYDLDFPALRKNKNIDNFLSRYKDTINKIRDLRMKAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLKSQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFPDDNDISKEAKNLICAFLTDREVRLGRNGVEEIKRHLFFKNDQWAWETLRDTVAPVVPDLSSDIDTSNFDDLEEDKGEEETFPIPKAFVGNQLPFVGFTYYSNRRYLSSANPNDNRTSSNADKSLQESLQKTIYKLEEQLHNEMQLKDEMEQKCRTSNIKLDKIMKELDEEGNQRRNLESTVSQIEKEKMLLQHRINEYQRKAEQENEKRRNVENEVSTLKDQLEDLKKVSQNSQL
  
Inhibitor
Name:
BDBM50382700
Synonyms:
CHEMBL1566648 | US9409868, 5
Type:
Small organic molecule
Emp. Form.:
C11H8BrN3O
Mol. Mass.:
278.105
SMILES:
Brc1cncc(c1)C(=O)Nc1ccncc1
Structure:
Search PDB for entries with ligand similarity: