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Target
Hexokinase-4
Ligand
BDBM239067
Substrate
n/a
Meas. Tech.
Activation Assay
pH
7.1±n/a
EC50
1500±n/a nM
Citation
 Kang, X; Long, W; Ma, C; Wang, Y; Shen, X; Hu, Y; Tan, F; Wang, Y Compound for increasing kinase active and application thereof US Patent  US9409900 Publication Date 8/9/2016 
Target
Name:
Hexokinase-4
Synonyms:
Gck | Gk | Glucokinase | HK IV | HK4 | HXK4_MOUSE | Hexokinase-4 | Hexokinase-D
Type:
Enzyme
Mol. Mass.:
52075.40
Organism:
Mus musculus (Mouse)
Description:
P52792
Residue:
465
Sequence:
MLDDRARMEATKKEKVEQILAEFQLQEEDLKKVMSRMQKEMDRGLKLETHQEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEAGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNIVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGNSGELDEFLLEYDRMVDESSVNPGQQLYEKIIGGKYMGELVRLVLLKLVEENLLFHGEASEQLRTRGAFETRFVSQVESDSGDRRQILNILSTLGLRPSVADCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPNCEITFIESEEGSGRGAALVSAVACKKACMLGQ
  
Inhibitor
Name:
BDBM239067
Synonyms:
US9409900, 78
Type:
Small organic molecule
Emp. Form.:
C27H29N5O5
Mol. Mass.:
503.5497
SMILES:
CN(C)C(=O)c1ccc(Oc2ccc(Nc3ccc(CCC(O)=O)cn3)cc2CN2CCCC2=O)cn1
Structure:
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