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Target
Orexin receptor type 2
Ligand
BDBM240154
Substrate
n/a
Meas. Tech.
Intracellular Calcium Assay
Temperature
310.15±n/a K
IC50
7±n/a nM
Comments
extracted
Citation
 Bolli, M; Boss, C; Brotschi, C; Heidmann, B; Sifferlen, T; Williams, JT Azetidine amide derivatives as orexin receptor antagonists US Patent  US9403813 Publication Date 8/2/2016 
Target
Name:
Orexin receptor type 2
Synonyms:
HCRTR2 | Hypocretin receptor type 2 | OX2R_HUMAN | Orexin receptor type 2 (OR 2) | Orexin receptor type 2 (OR-2) | Orexin receptor type 2 (OX2) | Orexin receptor type 2 (OX2R) | Orexin receptor type 2 (OxR2) | Ox-2-R | Ox2-R
Type:
Protein
Mol. Mass.:
50710.53
Organism:
Homo sapiens (Human)
Description:
O43614
Residue:
444
Sequence:
MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW
  
Inhibitor
Name:
BDBM240154
Synonyms:
US9403813, 59
Type:
Small organic molecule
Emp. Form.:
C24H22ClN5O2S
Mol. Mass.:
479.982
SMILES:
CN(C)c1nc(C(=O)N2CC[C@H]2c2nc(no2)-c2cccc(Cl)c2C)c(s1)-c1ccccc1
Structure:
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