Reaction Details Report a problem with these data
Target
Eukaryotic elongation factor 2 kinase
Ligand
BDBM293939
Substrate
n/a
Meas. Tech.
Kinase-Glo luminescent kinase assay
IC50
5022000±n/a nM
Citation
 Dodd, JH Compounds inhibiting eukaryotic elongation factor 2 kinase activity US Patent  US10106552 Publication Date 10/23/2018 
Target
Name:
Eukaryotic elongation factor 2 kinase
Synonyms:
Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase | EEF2K | EF2K_HUMAN | Eukaryotic elongation factor 2 kinase (EEF2K) | Eukaryotic elongation factor 2 kinase (eEF-2K) | Serine/threonine-protein kinase EEF2K | eEF-2 kinase | eEF-2K
Type:
Protein
Mol. Mass.:
82116.99
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
725
Sequence:
MADEDLIFRLEGVDGGQSPRAGHDGDSDGDSDDEEGYFICPITDDPSSNQNVNSKVNKYYSNLTKSERYSSSGSPANSFHFKEAWKHAIQKAKHMPDPWAEFHLEDIATERATRHRYNAVTGEWLDDEVLIKMASQPFGRGAMRECFRTKKLSNFLHAQQWKGASNYVAKRYIEPVDRDVYFEDVRLQMEAKLWGEEYNRHKPPKQVDIMQMCIIELKDRPGKPLFHLEHYIEGKYIKYNSNSGFVRDDNIRLTPQAFSHFTFERSGHQLIVVDIQGVGDLYTDPQIHTETGTDFGDGNLGVRGMALFFYSHACNRICESMGLAPFDLSPRERDAVNQNTKLLQSAKTILRGTEEKCGSPQVRTLSGSRPPLLRPLSENSGDENMSDVTFDSLPSSPSSATPHSQKLDHLHWPVFSDLDNMASRDHDHLDNHRESENSGDSGYPSEKRGELDDPEPREHGHSYSNRKYESDEDSLGSSGRVCVEKWNLLNSSRLHLPRASAVALEVQRLNALDLEKKIGKSILGKVHLAMVRYHEGGRFCEKGEEWDQESAVFHLEHAANLGELEAIVGLGLMYSQLPHHILADVSLKETEENKTKGFDYLLKAAEAGDRQSMILVARAFDSGQNLSPDRCQDWLEALHWYNTALEMTDCDEGGEYDGMQDEPRYMMLAREAEMLFTGGYGLEKDPQRSGDLYTQAAEAAMEAMKGRLANQYYQKAEEAWAQMEE
  
Inhibitor
Name:
BDBM293939
Synonyms:
US10106552, Compound 14
Type:
Small organic molecule
Emp. Form.:
C27H21Cl2F2N3OS
Mol. Mass.:
544.443
SMILES:
CC1(C)C\C(=C/c2cccc(Cl)c2F)c2nc3sc(C(N)=O)c(N)c3c(c2C1)-c1cccc(Cl)c1F |(-5.21,1.54,;-3.67,1.54,;-3.67,3.08,;-3.67,,;-2.34,-.77,;-2.34,-2.31,;-3.67,-3.08,;-5.01,-2.31,;-6.34,-3.08,;-6.34,-4.62,;-5.01,-5.39,;-5.01,-6.93,;-3.67,-4.62,;-2.34,-5.39,;-1.01,,;.33,-.77,;1.66,,;3.13,-.48,;4.03,.77,;5.57,.77,;6.34,2.1,;6.34,-.56,;3.13,2.02,;3.9,3.35,;1.66,1.54,;.33,2.31,;-1.01,1.54,;-2.34,2.31,;.33,3.85,;1.66,4.62,;1.66,6.16,;.33,6.93,;-1.01,6.16,;-2.34,6.93,;-1.01,4.62,;-2.34,3.85,)|
Structure:
Search PDB for entries with ligand similarity: