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Target
72 kDa type IV collagenase
Ligand
BDBM240828
Substrate
n/a
Meas. Tech.
MMP-2 Inhibition Assay
IC50
212970±1350 nM
Citation
 Zhang, X; Zhang, L; Zhang, J; Feng, J; Yuan, Y; Fang, H; Xu, W Design, synthesis and preliminary activity evaluation of novel 3-amino-2-hydroxyl-3-phenylpropanoic acid derivatives as aminopeptidase N/CD13 inhibitors. J Enzyme Inhib Med Chem 28:545-51 (2013) [PubMed]  Article 
Target
Name:
72 kDa type IV collagenase
Synonyms:
Gelatinase 2 (MMP-2)
Type:
Protein
Mol. Mass.:
73661.44
Organism:
Sus scrofa (Pig)
Description:
Q95JA4
Residue:
661
Sequence:
MTEARGARGALAGPLRALCVLGCLLGRAAAAPSPIIKFPGDVAPKTDKELAVQYLNTFYGCPKESCNLFVLKDTLKKMQKFFGLPQTGELDQSTIETMRKPRCGNPDVANYNFFPRKPKWDKTQITYRIIGYTPDLDPETVDDAFARAFRVWSDVTPLRFSRIHDGEADIMINFGRWEHGDGYPFDGKDGLLAHAFAPGPGVGGDSHFDDDELWTLGEGQVVRVKYGNADGEYCKFPFSFNGKEYNSCTDTGRSDGFLWCSTTYNFDKDGKYGFCPHEALFTMGGNADGQPCKFPFRFQGTSYNSCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTVGGNSEGAPCVFPFTFLGNKHESCTSAGRSDGKLWCATTANYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSEDPGALMAPIYTYTKNFRLSHDDVKGIQELYGASPDIDTGTGPTPTLGPVTPEICKQDIVFDGISQIRGEIFFFKDRFIWRTVTPRDKPMVAPAGATFWPELPEKIDAVYEAPQEEKAVFFAGNEYWVYSASTLERGYPKPLTSLGLPPDVQKVDAAFNWSKNKKTYIFAGDKFWRYNEVKKKMDPGFPKLIADAWNAIPDNLDAVVDLQGGGHSYFFKGAYYLKLENQSLKSVKFGSIKSDWLGC
  
Inhibitor
Name:
BDBM240828
Synonyms:
(2R,3S)-3-amino-2-hydroxy-N-((S)-2-(hydroxyamino)-2-oxo-1-phenylethyl)-3-phenylpropanamide hydrochloride (7e)
Type:
Small organic molecule
Emp. Form.:
C17H19N3O4
Mol. Mass.:
329.3505
SMILES:
N[C@H]([C@@H](O)C(=O)N[C@H](C(=O)NO)c1ccccc1)c1ccccc1 |r|
Structure:
Search PDB for entries with ligand similarity: