Reaction Details Report a problem with these data
Target
Egl nine homolog 1
Ligand
BDBM240924
Substrate
n/a
Meas. Tech.
HIF-PH Assay
pH
7.4±n/a
IC50
22830±n/a nM
Comments
extracted
Citation
 Ho, W; Zhao, H; Deng, S; Ng, D; Wright, LR; Wu, M; Zhou, X; Arend, MP; Flippin, LA 4-hydroxy-isoquinoline compounds as HIF hydroxylase inhibitors US Patent  US9409892 Publication Date 8/9/2016 
Target
Name:
Egl nine homolog 1
Synonyms:
C1orf12 | EGLN1 | EGLN1_HUMAN | Egl nine homolog 1 (EGLN1) | Hypoxia-inducible factor prolyl hydroxylase 2 (HIF-PH2) | Hypoxia-inducible factor prolyl hydroxylase 2 (HIFPH2) | Prolyl hydroxylase domain-containing protein 2 (PHD2)
Type:
Protein
Mol. Mass.:
46035.59
Organism:
Homo sapiens (Human)
Description:
Q9GZT9
Residue:
426
Sequence:
MANDSGGPGGPSPSERDRQYCELCGKMENLLRCSRCRSSFYCCKEHQRQDWKKHKLVCQGSEGALGHGVGPHQHSGPAPPAAVPPPRAGAREPRKAAARRDNASGDAAKGKVKAKPPADPAAAASPCRAAAGGQGSAVAAEAEPGKEEPPARSSLFQEKANLYPPSNTPGDALSPGGGLRPNGQTKPLPALKLALEYIVPCMNKHGICVVDDFLGKETGQQIGDEVRALHDTGKFTDGQLVSQKSDSSKDIRGDKITWIEGKEPGCETIGLLMSSMDDLIRHCNGKLGSYKINGRTKAMVACYPGNGTGYVRHVDNPNGDGRCVTCIYYLNKDWDAKVSGGILRIFPEGKAQFADIEPKFDRLLFFWSDRRNPHEVQPAYATRYAITVWYFDADERARAKVKYLTGEKGVRVELNKPSDSVGKDVF
  
Inhibitor
Name:
BDBM240924
Synonyms:
US9409892, 19
Type:
Small organic molecule
Emp. Form.:
C24H21N3O5
Mol. Mass.:
431.4406
SMILES:
OC(=O)C1(CNC(=O)c2nc(C#N)c3cc(Oc4ccccc4)ccc3c2O)CCCC1
Structure:
Search PDB for entries with ligand similarity: