Reaction Details
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Serum paraoxonase/arylesterase 1
Ligand
BDBM241976
Substrate
n/a
Meas. Tech.
PON Activity Assay
Ki
5.6300e+7± 2.6600e+7 nM
Citation
Dilek, EB; Küfrevioglu, ÿİ; Beydemir, Å¿ Impacts of some antibiotics on human serum paraoxonase 1 activity. J Enzyme Inhib Med Chem 28:758-64 (2013) [PubMed] Article More Info.:
Target
Name:
Serum paraoxonase/arylesterase 1
Synonyms:
A-esterase 1 | Aromatic esterase 1 | K-45 | PON | PON 1 | PON1 | PON1_HUMAN | Paraoxonase (PON1) | Paraoxonase (hPON1) | Paraoxonase 1 (PON1) | Serum aryldialkylphosphatase 1 | Serum paraoxonase 1 (PON1)
Type:
Enzyme
Mol. Mass.:
39719.73
Organism:
Human
Description:
P27169
Residue:
355
Sequence:
MAKLIALTLLGMGLALFRNHQSSYQTRLNALREVQPVELPNCNLVKGIETGSEDLEILPNGLAFISSGLKYPGIKSFNPNSPGKILLMDLNEEDPTVLELGITGSKFDVSSFNPHGISTFTDEDNAMYLLVVNHPDAKSTVELFKFQEEEKSLLHLKTIRHKLLPNLNDIVAVGPEHFYGTNDHYFLDPYLQSWEMYLGLAWSYVVYYSPSEVRVVAEGFDFANGINISPDGKYVYIAELLAHKIHVYEKHANWTLTPLKSLDFNTLVDNISVDPETGDLWVGCHPNGMKIFFYDSENPPASEVLRIQNILTEEPKVTQVYAENGTVLQGSTVASVYKGKLLIGTVFHKALYCEL
Inhibitor
Name:
BDBM241976
Synonyms:
Streptomycin sulfate
Type:
Small organic molecule
Emp. Form.:
C21H39N7O12
Mol. Mass.:
581.5741
SMILES:
[#6]-[#7]-[#6@@H]-1-[#6@@H](-[#8])-[#6@H](-[#8])-[#6@@H](-[#6]-[#8])-[#8]-[#6@@H]-1-[#8]-[#6@@H]1-[#6@@H](-[#8]-[#6@H]-2-[#6@H](-[#8])-[#6@@H](-[#8])-[#6@H](\[#7]=[#6](\[#7])-[#7])-[#6@@H](-[#8])-[#6@@H]-2\[#7]=[#6](\[#7])-[#7])-[#8]-[#6@H](-[#6])[C@@]1([#8])[#6]=O
Structure:
