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Target
Serine/threonine-protein kinase pim-1
Ligand
BDBM242409
Substrate
n/a
Meas. Tech.
Kinase-Glo Assay
Temperature
298.15±n/a K
IC50
68±n/a nM
Comments
extracted
Citation
 Xu, Y; Brenning, BG; Kultgen, SG; Liu, X; Saunders, M; Ho, K Substituted imidazo[1,2-b]pyridazines as protein kinase inhibitors US Patent  US9416132 Publication Date 8/16/2016 
Target
Name:
Serine/threonine-protein kinase pim-1
Synonyms:
PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:
Protein
Mol. Mass.:
35681.82
Organism:
Homo sapiens (Human)
Description:
P11309
Residue:
313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
  
Inhibitor
Name:
BDBM242409
Synonyms:
US9416132, 8-64
Type:
Small organic molecule
Emp. Form.:
C19H21ClN4O
Mol. Mass.:
356.849
SMILES:
CO[C@H]1CC[C@@H](CC1)Nc1ccn2ncc(-c3cccc(Cl)c3)c2n1 |r,wU:2.1,wD:5.8,(-8.05,2.84,;-6.72,3.63,;-5.38,2.87,;-3.95,3.62,;-2.62,2.85,;-2.62,1.31,;-3.95,.54,;-5.29,1.31,;-1.28,.54,;.05,1.31,;.05,2.85,;1.38,3.62,;2.72,2.85,;4.18,3.33,;5.09,2.08,;4.18,.84,;4.58,-.65,;3.49,-1.74,;3.89,-3.23,;5.38,-3.62,;6.47,-2.54,;7.95,-2.93,;6.07,-1.05,;2.72,1.31,;1.38,.54,)|
Structure:
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