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Target
Alpha-glucosidase MAL12
Ligand
BDBM18351
Substrate
n/a
Meas. Tech.
α-glucosidase Inhibitory Activity Assay
pH
7±n/a
Temperature
298.15±n/a K
IC50
2.780e+5± 1.7e+3 nM
Comments
extracted
Citation
 Kashima, Y; Yamaki, H; Suzuki, T; Miyazawa, M Structure-activity relationships of bergenin derivatives effect on a-glucosidase inhibition. J Enzyme Inhib Med Chem 28:1162-70 (2013) [PubMed]  Article 
Target
Name:
Alpha-glucosidase MAL12
Synonyms:
α-Glucosidase | MAL12 | MAL12_YEAST | MAL1S | Maltase | alpha-Glucosidase (α-Glucosidase)
Type:
Protein
Mol. Mass.:
68084.32
Organism:
Saccharomyces cerevisiae
Description:
P53341
Residue:
584
Sequence:
MTISDHPETEPKWWKEATIYQIYPASFKDSNNDGWGDLKGITSKLQYIKDLGVDAIWVCPFYDSPQQDMGYDISNYEKVWPTYGTNEDCFELIDKTHKLGMKFITDLVINHCSTEHEWFKESRSSKTNPKRDWFFWRPPKGYDAEGKPIPPNNWKSFFGGSAWTFDETTNEFYLRLFASRQVDLNWENEDCRRAIFESAVGFWLDHGVDGFRIDTAGLYSKRPGLPDSPIFDKTSKLQHPNWGSHNGPRIHEYHQELHRFMKNRVKDGREIMTVGEVAHGSDNALYTSAARYEVSEVFSFTHVEVGTSPFFRYNIVPFTLKQWKEAIASNFLFINGTDSWATTYIENHDQARSITRFADDSPKYRKISGKLLTLLECSLTGTLYVYQGQEIGQINFKEWPIEKYEDVDVKNNYEIIKKSFGKNSKEMKDFFKGIALLSRDHSRTPMPWTKDKPNAGFTGPDVKPWFLLNESFEQGINVEQESRDDDSVLNFWKRALQARKKYKELMIYGYDFQFIDLDSDQIFSFTKEYEDKTLFAALNFSGEEIEFSLPREGASLSFILGNYDDTDVSSRVLKPWEGRIYLVK
  
Inhibitor
Name:
BDBM18351
Synonyms:
(2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-triol, 10 | (2R,3R,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-triol | 1-Deoxynojirimycin | 1-deoxynojirimycin (DNJ) | CHEMBL307429 | US20230339856, Compound DNJ | US9181184, 1 | dNM
Type:
natural product
Emp. Form.:
C6H13NO4
Mol. Mass.:
163.1717
SMILES:
OC[C@H]1NC[C@H](O)[C@@H](O)[C@@H]1O
Structure:
Search PDB for entries with ligand similarity: