Reaction Details Report a problem with these data
Target
Carbonic anhydrase 2
Ligand
BDBM246576
Substrate
n/a
Meas. Tech.
In Vitro Inhibition Assay
IC50
4.93e+3±n/a nM
Citation
 Demirci, T; Arslan, M; Bilen, ÿ; Demir, D; Gençer, N; Arslan, O Synthesis and carbonic anhydrase inhibitory properties of 1,3-dicarbonyl derivatives of methylaminobenzene-sulfonamide. J Enzyme Inhib Med Chem 29:132-6 (2014) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 2
Synonyms:
CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II)
Type:
Enzyme
Mol. Mass.:
29250.71
Organism:
Homo sapiens (Human)
Description:
P00918
Residue:
260
Sequence:
MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
  
Inhibitor
Name:
BDBM246576
Synonyms:
4-((2,6-Dioxocyclohexylidene)methylamino)benzenesulfonamide (2a)
Type:
Small organic molecule
Emp. Form.:
C13H14N2O4S
Mol. Mass.:
294.326
SMILES:
[#7]S(=O)(=O)c1ccc(-[#7]\[#6]=[#6]-2\[#6](=O)-[#6]-[#6]-[#6]-[#6]-2=O)cc1
Structure:
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