Reaction Details Report a problem with these data
Target
D-amino-acid oxidase
Ligand
BDBM406234
Substrate
n/a
Meas. Tech.
In Vitro Measurements of porcine D-Amino Acid Oxidase (DAAO) Activities
IC50
55.0±n/a nM
Citation
 Tsai, GE; Wang, C; Hsieh, Y D-amino acid oxidase inhibitors and therapeutic uses thereof US Patent  US10336724 Publication Date 7/2/2019 
Target
Name:
D-amino-acid oxidase
Synonyms:
D-Amino Acid Oxidase (DAAO) | D-amino-acid oxidase (DAAO) | DAMOX | DAO | OXDA_PIG
Type:
Flavoprotein
Mol. Mass.:
39338.01
Organism:
Sus scrofa (pig)
Description:
Homodimer.
Residue:
347
Sequence:
MRVVVIGAGVIGLSTALCIHERYHSVLQPLDVKVYADRFTPFTTTDVAAGLWQPYTSEPSNPQEANWNQQTFNYLLSHIGSPNAANMGLTPVSGYNLFREAVPDPYWKDMVLGFRKLTPRELDMFPDYRYGWFNTSLILEGRKYLQWLTERLTERGVKFFLRKVESFEEVARGGADVIINCTGVWAGVLQPDPLLQPGRGQIIKVDAPWLKNFIITHDLERGIYNSPYIIPGLQAVTLGGTFQVGNWNEINNIQDHNTIWEGCCRLEPTLKDAKIVGEYTGFRPVRPQVRLEREQLRFGSSNTEVIHNYGHGGYGLTIHWGCALEVAKLFGKVLEERNLLTMPPSHL
  
Inhibitor
Name:
BDBM406234
Synonyms:
6-(naphthalen-1-ylmethyl)-3-oxo-2,3-dihydropyridazin-4-yl 3-(4-fluorophenethyl)-1H-pyrazole-5-carboxylate | US10336724, Compound 72
Type:
Small organic molecule
Emp. Form.:
C27H21FN4O3
Mol. Mass.:
468.479
SMILES:
Fc1ccc(CCc2cc([nH]n2)C(=O)Oc2cc(Cc3cccc4ccccc34)n[nH]c2=O)cc1
Structure:
Search PDB for entries with ligand similarity: