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Target
Hsp90 co-chaperone Cdc37
Ligand
BDBM50180301
Substrate
n/a
Meas. Tech.
Binding to JNPL3 brain Hsp90
EC50
60.7±n/a nM
Citation
 Chiosis, G; Greengard, P; Dou, F; Luo, W; He, H; Zatorska, D Treatment of neurodegenerative diseases through inhibition of HSP90 US Patent  US10336757 Publication Date 7/2/2019 
Target
Name:
Hsp90 co-chaperone Cdc37
Synonyms:
CDC37 | CDC37A | CDC37_HUMAN | Hsp90 co-chaperone
Type:
Molecular Chaperone
Mol. Mass.:
44453.72
Organism:
Homo sapiens (Human)
Description:
Q16543
Residue:
378
Sequence:
MVDYSVWDHIEVSDDEDETHPNIDTASLFRWRHQARVERMEQFQKEKEELDRGCRECKRKVAECQRKLKELEVAEGGKAELERLQAEAQQLRKEERSWEQKLEEMRKKEKSMPWNVDTLSKDGFSKSMVNTKPEKTEEDSEEVREQKHKTFVEKYEKQIKHFGMLRRWDDSQKYLSDNVHLVCEETANYLVIWCIDLEVEEKCALMEQVAHQTIVMQFILELAKSLKVDPRACFRQFFTKIKTADRQYMEGFNDELEAFKERVRGRAKLRIEKAMKEYEEEERKKRLGPGGLDPVEVYESLPEELQKCFDVKDVQMLQDAISKMDPTDAKYHMQRCIDSGLWVPNSKASEAKEGEEAGPGDPLLEAVPKTGDEKDVSV
  
Inhibitor
Name:
BDBM50180301
Synonyms:
2-FLUORO-8-[(6-IODO-1,3-BENZODIOXOL-5-YL)METHYL]-9-[3-(ISOPROPYLAMINO)PROPYL]-9H-PURIN-6-AMINE | 2-fluoro-8-((6-iodobenzo[d][1,3]dioxol-5-yl)methyl)-9-(3-(isopropylamino)propyl)-9H-purin-6-amine | 2-fluoro-8-(6-iodo-benzo[1,3]dioxol-5-ylmethyl)-9-(3-isopropylamino-propyl)adenine | CHEMBL200001 | US10336757, Compound PU-DZ8 | US10676476, Example 8
Type:
Small organic molecule
Emp. Form.:
C19H22FIN6O2
Mol. Mass.:
512.3199
SMILES:
CC(C)NCCCn1c(Cc2cc3OCOc3cc2I)nc2c(N)nc(F)nc12
Structure:
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