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Target
Hsp90 co-chaperone Cdc37
Ligand
BDBM406713
Substrate
n/a
Meas. Tech.
Binding to JNPL3 brain Hsp90
EC50
202±n/a nM
Citation
 Chiosis, G; Greengard, P; Dou, F; Luo, W; He, H; Zatorska, D Treatment of neurodegenerative diseases through inhibition of HSP90 US Patent  US10336757 Publication Date 7/2/2019 
Target
Name:
Hsp90 co-chaperone Cdc37
Synonyms:
CDC37 | CDC37A | CDC37_HUMAN | Hsp90 co-chaperone
Type:
Molecular Chaperone
Mol. Mass.:
44453.72
Organism:
Homo sapiens (Human)
Description:
Q16543
Residue:
378
Sequence:
MVDYSVWDHIEVSDDEDETHPNIDTASLFRWRHQARVERMEQFQKEKEELDRGCRECKRKVAECQRKLKELEVAEGGKAELERLQAEAQQLRKEERSWEQKLEEMRKKEKSMPWNVDTLSKDGFSKSMVNTKPEKTEEDSEEVREQKHKTFVEKYEKQIKHFGMLRRWDDSQKYLSDNVHLVCEETANYLVIWCIDLEVEEKCALMEQVAHQTIVMQFILELAKSLKVDPRACFRQFFTKIKTADRQYMEGFNDELEAFKERVRGRAKLRIEKAMKEYEEEERKKRLGPGGLDPVEVYESLPEELQKCFDVKDVQMLQDAISKMDPTDAKYHMQRCIDSGLWVPNSKASEAKEGEEAGPGDPLLEAVPKTGDEKDVSV
  
Inhibitor
Name:
BDBM406713
Synonyms:
US10336757, Compound PU-BSI16
Type:
Small organic molecule
Emp. Form.:
C20H22FIN6O3
Mol. Mass.:
540.33
SMILES:
Nc1nc(F)nc2n(CCCN3CCOCC3)c(Cc3cc4OCOc4cc3I)nc12
Structure:
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