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Target
Transthyretin
Ligand
BDBM408980
Substrate
n/a
Meas. Tech.
In vitro evaluation of inhibitory activity against WT-TTR
IC50
2200±30 nM
Citation
 Vieira Simões, CJ; Lourenço de Almeida, ZC; Vasconcelos Dias de Pinho e Melo, TM; Pontes Meireles Ferreira de Brito, RM; Silva Costa, DC; Cabral Cardoso Lopes, AL Bis-furan derivatives as transthyretin (TTR) stabilizers and amyloid inhibitors for the treatment of familial amyloid polyneuropathy (FAP) US Patent  US10377729 Publication Date 8/13/2019 
Target
Name:
Transthyretin
Synonyms:
ATTR | PALB | Prealbumin | TBPA | TTHY_HUMAN | TTR | Transthyretin (TTR)
Type:
Enzyme
Mol. Mass.:
15884.31
Organism:
Homo sapiens (Human)
Description:
P02766
Residue:
147
Sequence:
MASHRLLLLCLAGLVFVSEAGPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNPKE
  
Inhibitor
Name:
BDBM408980
Synonyms:
Thyroxine | US10377729, T4
Type:
Small organic molecule
Emp. Form.:
C15H11I4NO4
Mol. Mass.:
776.87
SMILES:
[NH3+][C@@H](Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C([O-])=O |r|
Structure:
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