Reaction Details Report a problem with these data
Target
Isoform PDE9A2 of High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)
Ligand
BDBM409949
Substrate
n/a
Meas. Tech.
IMAP FP Assay
Ki
7.20±n/a nM
Citation
 Cofre, V; Converso, A; Rodzinak, K Phenyl-cyanoquinolinone PDE9 inhibitors US Patent  US10370336 Publication Date 8/6/2019 
Target
Name:
Isoform PDE9A2 of High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)
Synonyms:
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2) | PDE9A | PDE9A_HUMAN | Phosphodiesterase 9A (PDE9A2) | Phosphodiesterase 9A2
Type:
Protein
Mol. Mass.:
61702.98
Organism:
Homo sapiens (Human)
Description:
O76083-2
Residue:
533
Sequence:
MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA
  
Inhibitor
Name:
BDBM409949
Synonyms:
4-(2-fluoro- 4-methyl- phenyl)-2- oxo-1H- quinoline-3- carbonitrile | US10370336, Example 1-11
Type:
Small organic molecule
Emp. Form.:
C17H11FN2O
Mol. Mass.:
278.2804
SMILES:
Cc1ccc(c(F)c1)-c1c(C#N)c(=O)[nH]c2ccccc12 |(,4.62,;,3.08,;1.33,2.31,;1.33,.77,;;-1.33,.77,;-2.67,,;-1.33,2.31,;,-1.54,;1.33,-2.31,;2.67,-1.54,;4,-.77,;1.33,-3.85,;2.67,-4.62,;,-4.62,;-1.33,-3.85,;-2.67,-4.62,;-4,-3.85,;-4,-2.31,;-2.67,-1.54,;-1.33,-2.31,)|
Structure:
Search PDB for entries with ligand similarity: