Reaction Details Report a problem with these data
Target
Baculoviral IAP repeat-containing protein 2 [174-256]
Ligand
BDBM298440
Substrate
n/a
Meas. Tech.
Enzyme Inhibition
IC50
40.0±n/a nM
Citation
 Baker, TM; Fyfe, MC; Jones, G; Thom, SM Kinase inhibitors US Patent  US10392346 Publication Date 8/27/2019 
Target
Name:
Baculoviral IAP repeat-containing protein 2 [174-256]
Synonyms:
API1 | BIRC2 | BIRC2_HUMAN | CIAP Bir2 | MIHB | RNF48
Type:
Enzyme Catalytic Domain
Mol. Mass.:
9527.07
Organism:
Homo sapiens (Human)
Description:
Q13490[174-256]
Residue:
83
Sequence:
TNPYSYAMSTEEARFLTYHMWPLTFLSPSELARAGFYYIGPGDRVACFACGGKLSNWEPKDDAMSEHRRHFPNCPFLENSLET
  
Inhibitor
Name:
BDBM298440
Synonyms:
4-((4-((4-(3-(5-(tert-Butyl)-2-methoxy-3-(methylsulfonamido)phenyl)ureido)naphthalen-1-yl)oxy)pyridin-2-yl)amino)-N-(2-(4-cyclopropylpiperazin-1-yl)ethyl)-2-methoxybenzamide | US10125100, Example 26 | US10392346, Example 26 | US10941115, Example 26 | US9751837, Example 26
Type:
Small organic molecule
Emp. Form.:
C45H54N8O7S
Mol. Mass.:
851.025
SMILES:
COc1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(cc(NS(C)(=O)=O)c4OC)C(C)(C)C)c4ccccc34)ccn2)ccc1C(=O)NCCN1CCN(CC1)C1CC1
Structure:
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