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Target
Baculoviral IAP repeat-containing protein 2 [260-351]
Ligand
BDBM412172
Substrate
n/a
Meas. Tech.
TR-FRET Assays for cIAP BIR3
IC50
7.00±n/a nM
Citation
 Flohr, A; Galley, G; Norcross, R; Zorn, N Dimeric compounds US Patent  US10398702 Publication Date 9/3/2019 
Target
Name:
Baculoviral IAP repeat-containing protein 2 [260-351]
Synonyms:
API1 | BIRC2 | BIRC2_HUMAN | CIAP Bir3 | MIHB | RNF48
Type:
Enzyme Catalytic Domain
Mol. Mass.:
10700.03
Organism:
Homo sapiens (Human)
Description:
Q13490[260-351]
Residue:
92
Sequence:
SISNLSMQTHAARMRTFMYWPSSVPVQPEQLASAGFYYVGRNDDVKCFCCDGGLRCWESGDDPWVEHAKWFPRCEFLIRMKGQEFVDEIQGR
  
Inhibitor
Name:
BDBM412172
Synonyms:
(3S)-2-[(2S)-3,3-dimethyl-2- [[(2S)-2- (methylamino)propanoyl] amino]butanoyl]-7-[[2- [[(3R)-6- [(4-fluorophenyl)methyl]-3- methyl-1-[2-[(2R,5R)-5- methyl-2-[[(3R)-3- methylmorpholin-4- yl]methyl]piperazin-1- yl]acetyl]-2H-indole-3- carbonyl]amino]acetyl] amino]-N-[(1R)-1,2,3,4- tetrahydronaphthalen-1-yl]- 3,4-dihydro-1H- isoquinoline-3- carboxamide;trihydrochloride | US10398702, Example 11
Type:
Small organic molecule
Emp. Form.:
C62H81FN10O7
Mol. Mass.:
1097.3677
SMILES:
CN[C@@H](C)C(=O)N[C@H](C(=O)N1Cc2cc(NC(=O)CNC(=O)[C@@]3(C)CN(C(=O)CN4C[C@@H](C)NC[C@@H]4CN4CCOC[C@H]4C)c4cc(Cc5ccc(F)cc5)ccc34)ccc2C[C@H]1C(=O)N[C@@H]1CCCc2ccccc12)C(C)(C)C |r|
Structure:
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