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Target
Baculoviral IAP repeat-containing protein 2 [260-351]
Ligand
BDBM412178
Substrate
n/a
Meas. Tech.
TR-FRET Assays for cIAP BIR3
IC50
2.00±n/a nM
Citation
 Flohr, A; Galley, G; Norcross, R; Zorn, N Dimeric compounds US Patent  US10398702 Publication Date 9/3/2019 
Target
Name:
Baculoviral IAP repeat-containing protein 2 [260-351]
Synonyms:
API1 | BIRC2 | BIRC2_HUMAN | CIAP Bir3 | MIHB | RNF48
Type:
Enzyme Catalytic Domain
Mol. Mass.:
10700.03
Organism:
Homo sapiens (Human)
Description:
Q13490[260-351]
Residue:
92
Sequence:
SISNLSMQTHAARMRTFMYWPSSVPVQPEQLASAGFYYVGRNDDVKCFCCDGGLRCWESGDDPWVEHAKWFPRCEFLIRMKGQEFVDEIQGR
  
Inhibitor
Name:
BDBM412178
Synonyms:
US10398702, Example 17 | tert-Butyl N-[(1 S)-2-[[(1 S)-2-[(1 S)-5-[3-(benzylamino)propanoylamino]-1-[(2,6-difluorophenyl)carbamoyl]isoindolin-2-yl]-2-oxo-1-tetrahydropyran-4-yl-ethyl]amino]-1-methyl-2-oxo-ethyl]-N-methyl-carbamate
Type:
Small organic molecule
Emp. Form.:
C59H73F3N10O8
Mol. Mass.:
1107.2683
SMILES:
CN[C@@H](C)C(=O)N[C@@H](C1CCOCC1)C(=O)N1Cc2ccc(NC(=O)CCNC(=O)[C@]3(C)CN(C(=O)CN4C[C@@H](C)NC[C@@H]4CN4CCOC[C@H]4C)c4cc(Cc5ccc(F)cc5)ccc34)cc2[C@H]1C(=O)Nc1c(F)cccc1F |r|
Structure:
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