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Target
Estrogen receptor
Ligand
BDBM412256
Substrate
n/a
Meas. Tech.
Biological Evaluation
EC50
29.8±n/a nM
Citation
 Liang, J; Ortwine, DF; Wang, X; Zbieg, J Tetrahydronaphthalene estrogen receptor modulators and uses thereof US Patent  US10399939 Publication Date 9/3/2019 
Target
Name:
Estrogen receptor
Synonyms:
ER | ER-alpha | ESR | ESR1 | ESR1_HUMAN | Estradiol receptor | Estrogen receptor | Estrogen receptor (ER alpha) | Estrogen receptor (ER-alpha) | Estrogen receptor alpha (ER alpha) | Estrogen receptor alpha (ER) | NR3A1 | Nuclear receptor subfamily 3 group A member 1
Type:
Protein
Mol. Mass.:
66230.44
Organism:
Homo sapiens (Human)
Description:
P03372
Residue:
595
Sequence:
MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV
  
Inhibitor
Name:
BDBM412256
Synonyms:
(7S,8R)-8-(4-(2-(3- (fluoromethyl)azetidin- 1-yl)ethoxy)phenyl)- 7-phenyl-5,6,7,8- tetrahydronaphthalen- 1-ol | US10399939, Example 135
Type:
Small organic molecule
Emp. Form.:
C28H30FNO2
Mol. Mass.:
431.5417
SMILES:
Oc1cccc2CC[C@@H]([C@H](c3ccc(OCCN4CC(CF)C4)cc3)c12)c1ccccc1 |r|
Structure:
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