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Target
Tyrosine-protein kinase BTK [C481S]
Ligand
BDBM412831
Substrate
n/a
Meas. Tech.
BTKC481S Binding Affinity
IC50
<10±n/a nM
Citation
 Guisot, N Pyrazolopyrimidine derivatives as BTK inhibitors for the treatment of cancer US Patent  US10399989 Publication Date 9/3/2019 
Target
Name:
Tyrosine-protein kinase BTK [C481S]
Synonyms:
AGMX1 | ATK | BPK | BTK | BTK C481S | BTK_HUMAN | Tyrosine-protein kinase BTK (C481S) | Tyrosine-protein kinase BTK C481S
Type:
Enzyme Catalytic Domain
Mol. Mass.:
76273.88
Organism:
Homo sapiens (Human)
Description:
Q06187[C481S]
Residue:
659
Sequence:
MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGSLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES
  
Inhibitor
Name:
BDBM412831
Synonyms:
US10399989, Example 44 | US10611766, Example 44
Type:
Small organic molecule
Emp. Form.:
C25H24N6O3
Mol. Mass.:
456.4965
SMILES:
COc1ccccc1C(=O)NCc1ccc(cc1)-c1nn([C@H]2C[C@@H](O)C=C2)c2ncnc(N)c12 |r,c:27|
Structure:
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