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Target
Tyrosine-protein kinase JAK3 [811-1124]
Ligand
BDBM50402074
Substrate
n/a
Meas. Tech.
Kinase Assay
pH
7.5±n/a
IC50
950±n/a nM
Comments
extracted
Citation
 Bursulaya, B; Fisch, A; Lajiness, JP; Machauer, R; Malekar, S; Petrassi, HM; Ramazani, F; Remond, A; Ullrich, T; Usselmann, P; Vangrevelinghe, E Substituted indazoles for treating tendon and/or ligament injuries US Patent  US10112907 Publication Date 10/30/2018 
Target
Name:
Tyrosine-protein kinase JAK3 [811-1124]
Synonyms:
JAK3 | JAK3 (aa 811-1124) | JAK3_HUMAN | Tyrosine-protein kinase JAK3 (aa 811-1124)
Type:
Protein
Mol. Mass.:
35601.85
Organism:
Homo sapiens (Human)
Description:
P52333[811-1124]
Residue:
314
Sequence:
CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS
  
Inhibitor
Name:
BDBM50402074
Synonyms:
CHEMBL2206059 | US10112907, Example 00024 | US10766894, Compound TABLE 1.9 | US11203595, TABLE 1.9
Type:
Small organic molecule
Emp. Form.:
C17H21N5O2S
Mol. Mass.:
359.446
SMILES:
CS(=O)(=O)NCc1nc2cnc3[nH]ccc3c2n1[C@@H]1C[C@H]2CC[C@@H]1C2 |r|
Structure:
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