Reaction Details Report a problem with these data
Target
Metalloproteinase inhibitor 2
Ligand
BDBM413580
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
21.0±n/a nM
Citation
 Prades Cosano, R; Seco Moral, J; Tarragó Clua, MT Gelatinase inhibitors and use thereof US Patent  US10414797 Publication Date 9/17/2019 
Target
Name:
Metalloproteinase inhibitor 2
Synonyms:
Metalloproteinase inhibitor 2 (TIMP2) | TIMP-2 | TIMP2 | TIMP2_CRILO | Tissue inhibitor of metalloproteinases 2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
21943.02
Organism:
Cricetulus longicaudatus (Long-tailed dwarf hamster) (Chinese hamster)
Description:
Q60453
Residue:
196
Sequence:
RACSCSPVHPQQAFCNADVVIRAKAVSEKEVDSGNDIYGNPIKRIQYEIKQIKMFKGPDKDIEFIYTAPSSAVCGVSLDVGGKKEYLIAGKAEGDGKMHITLCDFIVPWDTLSTTQKKSLNHRYQMGCECKITRCPMIPCYISSPDECLWMDWVTEKSINGHQAKFFACIKRSDGSCAWYRGAAPPKQEFLDIEDP
  
Inhibitor
Name:
BDBM413580
Synonyms:
(2 S)-1-[(2S)-2-[acetyl(methyl)amino]propanoyl]-N-[(1S)-1-[[(1S)-3-[(3,5-difluorobenzoyl)amino]-1-(hydroxycarbamoyl)propyl]carbamoyl]-2-methyl-butyl]-N-methyl-pyrrolidine-2-carboxamide | US10414797, Example 12
Type:
Small organic molecule
Emp. Form.:
C29H42F2N6O7
Mol. Mass.:
624.6766
SMILES:
CCC(C)[C@H](N(C)C(=O)[C@@H]1CCCN1C(=O)[C@H](C)N(C)C(C)=O)C(=O)N[C@@H](CCNC(=O)c1cc(F)cc(F)c1)C(=O)NO |r|
Structure:
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