Reaction Details Report a problem with these data
Target
Tyrosine-protein kinase JAK2 [828-1132]
Ligand
BDBM380039
Substrate
n/a
Meas. Tech.
In Vitro JAK Kinase Assay
IC50
>700±n/a nM
Citation
 Li, Y; Zhuo, J; Qian, D; Mei, S Bipyrazole derivatives as JAK inhibitors US Patent  US10435392 Publication Date 10/8/2019 
Target
Name:
Tyrosine-protein kinase JAK2 [828-1132]
Synonyms:
JAK2 | JAK2 (aa 828-1132) | JAK2_HUMAN | Tyrosine-protein kinase JAK2
Type:
n/a
Mol. Mass.:
35579.28
Organism:
Homo sapiens (Human)
Description:
O60674[828-1132]
Residue:
305
Sequence:
GALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG
  
Inhibitor
Name:
BDBM380039
Synonyms:
5-[3-(Cyanomethyl)-3-(3′-methyl-1H,1′H-4,4′-bipyrazol-1-yl)azetidin-1-yl]-N-[(1S)-2,2,2-trifluoro-1-methylethyl]pyrazine-2-carboxamide trifluoroacetate | US10435392, Example 1 | US11591318, Example 1 | US9926301, Example 1
Type:
Small organic molecule
Emp. Form.:
C20H20F3N9O
Mol. Mass.:
459.4277
SMILES:
C[C@H](NC(=O)c1cnc(cn1)N1CC(CC#N)(C1)n1cc(cn1)-c1cn[nH]c1C)C(F)(F)F |r|
Structure:
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