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Target
Tyrosine-protein kinase JAK1 [837-1142]
Ligand
BDBM380422
Substrate
n/a
Meas. Tech.
In Vitro JAK Kinase Assay
IC50
<300±n/a nM
Citation
 Li, Y; Zhuo, J; Qian, D; Mei, S Bipyrazole derivatives as JAK inhibitors US Patent  US10435392 Publication Date 10/8/2019 
Target
Name:
Tyrosine-protein kinase JAK1 [837-1142]
Synonyms:
JAK1 | JAK1 (aa 837-1142) | JAK1A | JAK1B | JAK1_HUMAN | Tyrosine-protein kinase JAK1 | Tyrosine-protein kinase JAK1 (837-1142) | Tyrosine-protein kinase JAK1 (aa 837-1142)
Type:
n/a
Mol. Mass.:
35230.04
Organism:
Homo sapiens (Human)
Description:
P23458[837-1142]
Residue:
306
Sequence:
FFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSF
  
Inhibitor
Name:
BDBM380422
Synonyms:
4-[3-(Cyanomethyl)-3-(3′-methyl-1H,1′H-4,4′-bipyrazol-1-yl)azetidin-1-yl]-N-isopropylbenzamide trifluoroacetate | US10435392, Example 3 | US9926301, Example 3
Type:
Small organic molecule
Emp. Form.:
C22H25N7O
Mol. Mass.:
403.4802
SMILES:
CC(C)NC(=O)c1ccc(cc1)N1CC(CC#N)(C1)n1cc(cn1)-c1c[nH]nc1C
Structure:
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