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Target
Tyrosine-protein kinase JAK2 [828-1132]
Ligand
BDBM380442
Substrate
n/a
Meas. Tech.
In Vitro JAK Kinase Assay
IC50
>1000±n/a nM
Citation
 Li, Y; Zhuo, J; Qian, D; Mei, S Bipyrazole derivatives as JAK inhibitors US Patent  US10435392 Publication Date 10/8/2019 
Target
Name:
Tyrosine-protein kinase JAK2 [828-1132]
Synonyms:
JAK2 | JAK2 (aa 828-1132) | JAK2_HUMAN | Tyrosine-protein kinase JAK2
Type:
n/a
Mol. Mass.:
35579.28
Organism:
Homo sapiens (Human)
Description:
O60674[828-1132]
Residue:
305
Sequence:
GALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG
  
Inhibitor
Name:
BDBM380442
Synonyms:
5-[3-(Cyanomethyl)-3-(3,3′-dimethyl-1H,1′H-4,4′-bipyrazol-1-yl)azetidin-1-yl]-N-isopropylpyrazine-2-carboxamide trifluoroacetate | US10435392, Example 6 | US11591318, Example 6 | US9926301, Example 6
Type:
Small organic molecule
Emp. Form.:
C21H25N9O
Mol. Mass.:
419.4829
SMILES:
CC(C)NC(=O)c1cnc(cn1)N1CC(CC#N)(C1)n1cc(c(C)n1)-c1c[nH]nc1C
Structure:
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