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Target
Orexin receptor type 2
Ligand
BDBM414503
Substrate
n/a
Meas. Tech.
FLIPR Ca2+ Flux Assay
IC50
292±n/a nM
Citation
 Kuduk, SD; Liverton, N; Luo, Y Oxazole orexin receptor antagonists US Patent  US10435398 Publication Date 10/8/2019 
Target
Name:
Orexin receptor type 2
Synonyms:
HCRTR2 | Hypocretin receptor type 2 | OX2R_HUMAN | Orexin receptor type 2 (OR 2) | Orexin receptor type 2 (OR-2) | Orexin receptor type 2 (OX2) | Orexin receptor type 2 (OX2R) | Orexin receptor type 2 (OxR2) | Ox-2-R | Ox2-R
Type:
Protein
Mol. Mass.:
50710.53
Organism:
Homo sapiens (Human)
Description:
O43614
Residue:
444
Sequence:
MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW
  
Inhibitor
Name:
BDBM414503
Synonyms:
N-Ethyl-N-{2-[4-(1-hydroxy- 1-methylethyl)-5-methyl-1,3- oxazol-2-yl]ethyl}-2-(1H- pyrazol-1-yl)benzamide | US10435398, Example 17
Type:
Small organic molecule
Emp. Form.:
C21H26N4O3
Mol. Mass.:
382.4561
SMILES:
CCN(CCc1nc(c(C)o1)C(C)(C)O)C(=O)c1ccccc1-n1cccn1
Structure:
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