Reaction Details Report a problem with these data
Target
Orexin receptor type 2
Ligand
BDBM414504
Substrate
n/a
Meas. Tech.
FLIPR Ca2+ Flux Assay
IC50
145±n/a nM
Citation
 Kuduk, SD; Liverton, N; Luo, Y Oxazole orexin receptor antagonists US Patent  US10435398 Publication Date 10/8/2019 
Target
Name:
Orexin receptor type 2
Synonyms:
HCRTR2 | Hypocretin receptor type 2 | OX2R_HUMAN | Orexin receptor type 2 (OR 2) | Orexin receptor type 2 (OR-2) | Orexin receptor type 2 (OX2) | Orexin receptor type 2 (OX2R) | Orexin receptor type 2 (OxR2) | Ox-2-R | Ox2-R
Type:
Protein
Mol. Mass.:
50710.53
Organism:
Homo sapiens (Human)
Description:
O43614
Residue:
444
Sequence:
MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW
  
Inhibitor
Name:
BDBM414504
Synonyms:
2-(1-(difluoro- methyl)cyclopropyl)- N-ethyl-N-(2-(4-(2- hydroxypropan-2-yl)-5- methyloxazol-2- yl)ethyl)benzamide | US10435398, Example 18b
Type:
Small organic molecule
Emp. Form.:
C22H28F2N2O3
Mol. Mass.:
406.4661
SMILES:
CCN(CCc1nc(c(C)o1)C(C)(C)O)C(=O)c1ccccc1C1(CC1)C(F)F
Structure:
Search PDB for entries with ligand similarity: