Reaction Details Report a problem with these data
Target
Orexin receptor type 2
Ligand
BDBM414511
Substrate
n/a
Meas. Tech.
FLIPR Ca2+ Flux Assay
IC50
68.0±n/a nM
Citation
 Kuduk, SD; Liverton, N; Luo, Y Oxazole orexin receptor antagonists US Patent  US10435398 Publication Date 10/8/2019 
Target
Name:
Orexin receptor type 2
Synonyms:
HCRTR2 | Hypocretin receptor type 2 | OX2R_HUMAN | Orexin receptor type 2 (OR 2) | Orexin receptor type 2 (OR-2) | Orexin receptor type 2 (OX2) | Orexin receptor type 2 (OX2R) | Orexin receptor type 2 (OxR2) | Ox-2-R | Ox2-R
Type:
Protein
Mol. Mass.:
50710.53
Organism:
Homo sapiens (Human)
Description:
O43614
Residue:
444
Sequence:
MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW
  
Inhibitor
Name:
BDBM414511
Synonyms:
N-(2,2-Difluoroethyl)-N-{2-[4-(1-hydroxy-1-methylethyl)-5-methyl-1,3-oxazol-2-yl]ethyl}-2-(2H-1,2,3-triazol-2-yl)benzamide | US10435398, Example 24
Type:
Small organic molecule
Emp. Form.:
C19H21F2N5O5
Mol. Mass.:
437.3973
SMILES:
COC(=O)C(NC(=O)CCN(CC(F)F)C(=O)c1ccccc1-n1nccn1)C(C)=O
Structure:
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