Reaction Details Report a problem with these data
Target
Bromodomain-containing protein 4 [42-168]
Ligand
BDBM343472
Substrate
n/a
Meas. Tech.
AlphaScreen Assay
IC50
5500±n/a nM
Citation
 Rodgers, JD; Shepard, S; Wang, H; Shao, L Tricyclic heterocycles as bet protein inhibitors US Patent  US10442803 Publication Date 10/15/2019 
Target
Name:
Bromodomain-containing protein 4 [42-168]
Synonyms:
BRD4 | BRD4 BD1 (aa 42-168) | BRD4_HUMAN | Bromodomain-containing protein 4 Bromo Domain 1 | HUNK1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
15054.68
Organism:
Homo sapiens (Human)
Description:
O60885[42-168]
Residue:
127
Sequence:
STNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE
  
Inhibitor
Name:
BDBM343472
Synonyms:
US10442803, Example 71 | US11091484, Example 71 | US9777003, Example 71
Type:
Small organic molecule
Emp. Form.:
C20H18N6
Mol. Mass.:
342.3971
SMILES:
Cc1nnc2ccc3n(Cc4ccccc4)c(cc3n12)-c1cncn1C
Structure:
Search PDB for entries with ligand similarity: