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Target
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 [329-824]
Ligand
BDBM355948
Substrate
n/a
Meas. Tech.
Biochemical Assay
IC50
0.003±n/a nM
Citation
 Soldermann, CP; Quancard, J; Schlapbach, A; Simic, O; Tintelnot-Blomley, M; Zoller, T Pyrazolo pyrimidine derivatives and their use as MALT1 inhbitors US Patent  US10442808 Publication Date 10/15/2019 
Target
Name:
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 [329-824]
Synonyms:
MALT1 | MALT1_HUMAN | MLT | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1)(aa 329-824)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
55563.19
Organism:
Homo sapiens (Human)
Description:
amino acids 329-824
Residue:
495
Sequence:
NKEQTTDQPLAKDKVALLIGNMNYREHPKLKAPLVDVYELTNLLRQLDFKVVSLLDLTEYEMRNAVDEFLLLLDKGVYGLLYYAGHGYENFGNSFMVPVDAPNPYRSENCLCVQNILKLMQEKETGLNVFLLDMCRKRNDYDDTIPILDALKVTANIVFGYATCQGAEAFEIQHSGLANGIFMKFLKDRLLEDKKITVLLDEVAEDMGKCHLTKGKQALEIRSSLSEKRALTDPIQGTEYSAESLVRNLQWAKAHELPESMCLKFDCGVQIQLGFAAEFSNVMIIYTSIVYKPPEIIMCDAYVTDFPLDLDIDPKDANKGTPEETGSYLVSKDLPKHCLYTRLSSLQKLKEHLVFTVCLSYQYSGLEDTVEDKQEVNVGKPLIAKLDMHRGLGRKTCFQTCLMSNGPYQSSAATSGGAGHYHSLQDPFHGVYHSHPGNPSNVTPADSCHCSRTPDAFISSFAHHASCHFSRSNVPVETTDEIPFSFSDRLRISEK
  
Inhibitor
Name:
BDBM355948
Synonyms:
1-(5-chloro-6-(2H- 1,2,3-triazol-2- yl)pyridin-3-yl)-3-(2- methyl-7-(1- methylcyclopropyl) pyrazolo[1,5- a]pyrimidin-6-yl)urea | US10442808, Example 72 | US9815842, Example 72
Type:
Small organic molecule
Emp. Form.:
C19H18ClN9O
Mol. Mass.:
423.859
SMILES:
Cc1cc2ncc(NC(=O)Nc3cnc(c(Cl)c3)-n3nccn3)c(n2n1)C1(C)CC1
Structure:
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