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Target
Neuronal acetylcholine receptor subunit alpha-7
Ligand
BDBM397116
Substrate
n/a
Meas. Tech.
Measurement of Human α7 Nicotinic Acetylcholine Receptor (nAChR)'s Activity
EC50
>1000±n/a nM
Citation
 Maeng, CY; Jang, YK; Cha, SB; Shin, HW; Joung, CM; Yi, EJ Pharmaceutical composition comprising pyridone derivatives US Patent  US10456385 Publication Date 10/29/2019 
Target
Name:
Neuronal acetylcholine receptor subunit alpha-7
Synonyms:
ACHA7_HUMAN | CHRNA7 | Cholinergic, Nicotinic Alpha7 | NACHRA7 | Neuronal acetylcholine receptor protein alpha-7 subunit | Neuronal acetylcholine receptor subunit alpha-7 (nAChR-alpha 7) | Nicotinic acetylcholine receptor alpha-7 (alpha7 nAChR)
Type:
n/a
Mol. Mass.:
56448.33
Organism:
Homo sapiens (Human)
Description:
CHRNA7 (NACHRA7)
Residue:
502
Sequence:
MRCSPGGVWLALAASLLHVSLQGEFQRKLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA
  
Inhibitor
Name:
BDBM397116
Synonyms:
N-(1-azabicyclo[2.2.2]octan-3-yl)-6-oxo-1-[3-phenyl-5-isoxazolyl)-3-pyridinecarboxamide | US10456385, Example 9 | US9987259, Example 9
Type:
Small organic molecule
Emp. Form.:
C22H22N4O3
Mol. Mass.:
390.4351
SMILES:
O=C(NC1CN2CCC1CC2)c1ccc(=O)n(c1)-c1cc(no1)-c1ccccc1 |(3.49,1.92,;3.49,.38,;4.83,-.39,;6.16,.38,;6.16,1.93,;7.5,2.7,;8.83,1.93,;8.83,.38,;7.5,-.39,;8.21,.96,;6.73,1.36,;2.16,-.39,;2.16,-1.93,;.83,-2.7,;-.51,-1.93,;-1.84,-2.7,;-.51,-.39,;.83,.38,;-1.84,.38,;-3.3,-.09,;-4.21,1.15,;-3.3,2.4,;-1.84,1.92,;-5.75,1.15,;-6.52,2.49,;-8.06,2.49,;-8.83,1.15,;-8.06,-.18,;-6.52,-.18,)|
Structure:
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