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Target
Neuronal acetylcholine receptor subunit alpha-7
Ligand
BDBM397118
Substrate
n/a
Meas. Tech.
Measurement of Human α7 Nicotinic Acetylcholine Receptor (nAChR)'s Activity
EC50
<100±n/a nM
Citation
 Maeng, CY; Jang, YK; Cha, SB; Shin, HW; Joung, CM; Yi, EJ Pharmaceutical composition comprising pyridone derivatives US Patent  US10456385 Publication Date 10/29/2019 
Target
Name:
Neuronal acetylcholine receptor subunit alpha-7
Synonyms:
ACHA7_HUMAN | CHRNA7 | Cholinergic, Nicotinic Alpha7 | NACHRA7 | Neuronal acetylcholine receptor protein alpha-7 subunit | Neuronal acetylcholine receptor subunit alpha-7 (nAChR-alpha 7) | Nicotinic acetylcholine receptor alpha-7 (alpha7 nAChR)
Type:
n/a
Mol. Mass.:
56448.33
Organism:
Homo sapiens (Human)
Description:
CHRNA7 (NACHRA7)
Residue:
502
Sequence:
MRCSPGGVWLALAASLLHVSLQGEFQRKLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA
  
Inhibitor
Name:
BDBM397118
Synonyms:
N-[(3R)-1-azabicyclo[2.2.2]octan-3-yl]-1-(5-methyl-2-thiazolyl)-6-oxo-3-pyridinecarboxamide | US10456385, Example 11 | US9987259, Example 11
Type:
Small organic molecule
Emp. Form.:
C17H20N4O2S
Mol. Mass.:
344.431
SMILES:
Cc1cnc(s1)-n1cc(ccc1=O)C(=O)N[C@H]1CN2CCC1CC2 |r,wU:16.17,(-7.29,1.15,;-5.75,1.15,;-4.84,2.4,;-3.38,1.92,;-3.38,.38,;-4.84,-.09,;-2.05,-.39,;-.71,.38,;.62,-.39,;.62,-1.93,;-.71,-2.7,;-2.05,-1.93,;-3.38,-2.7,;1.95,.38,;1.95,1.92,;3.29,-.39,;4.62,.38,;4.62,1.93,;5.96,2.7,;7.29,1.93,;7.29,.38,;5.96,-.39,;6.67,1.36,;5.19,1.36,)|
Structure:
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