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Target
Neuronal acetylcholine receptor subunit alpha-7
Ligand
BDBM397136
Substrate
n/a
Meas. Tech.
Measurement of Human α7 Nicotinic Acetylcholine Receptor (nAChR)'s Activity
EC50
300±n/a nM
Citation
 Maeng, CY; Jang, YK; Cha, SB; Shin, HW; Joung, CM; Yi, EJ Pharmaceutical composition comprising pyridone derivatives US Patent  US10456385 Publication Date 10/29/2019 
Target
Name:
Neuronal acetylcholine receptor subunit alpha-7
Synonyms:
ACHA7_HUMAN | CHRNA7 | Cholinergic, Nicotinic Alpha7 | NACHRA7 | Neuronal acetylcholine receptor protein alpha-7 subunit | Neuronal acetylcholine receptor subunit alpha-7 (nAChR-alpha 7) | Nicotinic acetylcholine receptor alpha-7 (alpha7 nAChR)
Type:
n/a
Mol. Mass.:
56448.33
Organism:
Homo sapiens (Human)
Description:
CHRNA7 (NACHRA7)
Residue:
502
Sequence:
MRCSPGGVWLALAASLLHVSLQGEFQRKLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA
  
Inhibitor
Name:
BDBM397136
Synonyms:
N-(1-azabicyclo[2.2.2]octan-3-yl)-6-oxo-1-[5-(phenylmethyl)-2-thiazolyl)]-3-pyridine carboxamide | US10456385, Example 29 | US9987259, Example 29
Type:
Small organic molecule
Emp. Form.:
C23H24N4O2S
Mol. Mass.:
420.527
SMILES:
O=C(NC1CN2CCC1CC2)c1ccc(=O)n(c1)-c1ncc(Cc2ccccc2)s1 |(3.49,.69,;3.49,-.85,;4.83,-1.62,;6.16,-.85,;6.16,.69,;7.5,1.46,;8.83,.69,;8.83,-.85,;7.5,-1.62,;8.21,-.27,;6.73,.13,;2.16,-1.62,;2.16,-3.16,;.83,-3.93,;-.51,-3.16,;-1.84,-3.93,;-.51,-1.62,;.83,-.85,;-1.84,-.85,;-1.84,.69,;-3.3,1.17,;-4.21,-.08,;-5.75,-.08,;-6.52,1.26,;-5.75,2.59,;-6.52,3.93,;-8.06,3.93,;-8.83,2.59,;-8.06,1.26,;-3.3,-1.32,)|
Structure:
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